sip3 - septin interacting protein 3 (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables p53 binding activity and ubiquitin protein ligase activity. Involved in several processes, including endoplasmic reticulum unfolded protein response; intestinal stem cell homeostasis; and regulation of protein metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum quality control compartment. Is expressed in several structures, including adult head; foregut primordium; gland; gut section; and salivary gland body primordium. Orthologous to human SYVN1 (synoviolin 1).
- CG1937
- Dmel\CG1937
- HRD1
- Hrd1
- Sip3
- dHRD1
- dSyno
- hrd1
- CG1937-PA
- CG1937-PB
- septin-interacting protein 3
- sip3-PA
- sip3-PB
- synoviolin
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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