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Nup98-96 - Nucleoporin 98-96kD (fruit fly)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-17
Description
Enables promoter-enhancer loop anchoring activity and promoter-specific chromatin binding activity. Involved in several processes, including heat shock-mediated polytene chromosome puffing; nucleocytoplasmic transport; and positive regulation of macromolecule biosynthetic process. Located in chromosome; cytoplasm; and nucleus. Part of nuclear pore. Is expressed in adult head; cyst progenitor cell; and male germline stem cell. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human NUP98 (nucleoporin 98 and 96 precursor).

1 Names and Identifiers

1.1 Synonyms

  • CG10198
  • CG10201
  • Dmel\CG10198
  • NUP98
  • NUP98-NUP96
  • Nup
  • Nup 96
  • Nup 98
  • Nup-98
  • Nup96
  • Nup96-98
  • Nup98
  • Nup98-Nup96
  • Nup98/96
  • l(3)95BCd
  • nup145
  • nup98
  • nup98-96
  • nucleoporin 98-96kD
  • CG10198-PA
  • CG10198-PC
  • CG10198-PD
  • Nup98
  • Nup98-96-PA
  • Nup98-96-PC
  • Nup98-96-PD
  • nucleoporin 96
  • nucleoporin 98
  • nucleoporin 98-96
  • nucleoporin98-96

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 Enzyme Commission (EC) Number

1.2.5 FlyBase ID

1.2.6 VEuPathDB ID

1.2.7 Wikidata

2 Proteins

2.1 Protein Function

Part of the nuclear pore complex (NPC) (PMID: 25197089). Required for MAD import as part of the Nup107-160 complex and required for nuclear export of Moe probably via its association with Rae1 (PMID: 20547758, PMID: 28554770). Plays a role in nuclear mRNA export (PMID: 28554770). Promotes cell antiviral response by up-regulating FoxK-dependent antiviral gene transcription (PMID: 25197089, PMID: 25852164). In germline stem cells, involved in their maintenance and division together with the TGF-Beta and EGFR signaling pathways (PMID: 21949861). In larval lymph glands, has a role in the maintenance of hematopoiesis by regulating Pvr expression (PMID: 25201876).

Part of the nuclear pore complex (NPC) (PMID: 25310983). In the nucleoplasm, binds to transcriptionally active chromatin with a preference for regulatory regions; co-localizes with RNA polymerase II in a RNA-independent manner and before transition into transcription elongation (PMID: 20144760, PMID: 20144761, PMID: 28366641). Plays a role in the transcriptional memory process by stabilizing enhancer-promoter loops and by mediating anchoring of chromatin to the nuclear pore complex region (PMID: 28366641). During larval development, interacts with trx and MBD-R2 and regulates transcription of developmental genes including ecdysone-responsive genes such as Eip74 and E23 (PMID: 20144761, PMID: 25310983, PMID: 28366641).

Part of the nuclear pore complex (NPC).

2.2 Protein Isoforms

Isoform
Isoform A
UniProt ID
RefSeq Accession
Isoform
Isoform A
UniProt ID
RefSeq Accession
Isoform
Isoform C
UniProt ID
RefSeq Accession

2.3 Protein 3D Structures

2.3.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.4 Protein Targets

3 BioAssays

3.1 RNAi BioAssays

4 Interactions and Pathways

4.1 Interactions

4.2 Pathways

5 Biochemical Reactions

6 Expression

7 Literature

7.1 Consolidated References

7.2 Gene-Chemical Co-Occurrences in Literature

7.3 Gene-Gene Co-Occurrences in Literature

7.4 Gene-Disease Co-Occurrences in Literature

8 Patents

9 Classification

9.1 Gene Ontology: Biological Process

9.2 Gene Ontology: Cellular Component

9.3 Gene Ontology: Molecular Function

10 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. Database of Interacting Proteins (DIP)
    LICENSE
    All DIP database records available under the terms set by the Creative Commons Attribution-NoDerivs License.
    https://dip.doe-mbi.ucla.edu/dip/termsofuse.html
  6. STRING: functional protein association networks
  7. FlyBase
    LICENSE
    All annotations and data produced by FlyBase that are accessible from flybase.org are distributed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
    https://wiki.flybase.org/wiki/FlyBase:About#FlyBase_Licenses_and_Availability
  8. NCBI Gene Expression Omnibus (GEO)
  9. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  10. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  11. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  12. Wikidata
  13. Gene Ontology (GO)
    LICENSE
    Gene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)
    http://geneontology.org/docs/go-citation-policy/
  14. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
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