Nup98-96 - Nucleoporin 98-96kD (fruit fly)
- Create:2016-09-14
- Modify:2025-01-17
- CG10198
- CG10201
- Dmel\CG10198
- NUP98
- NUP98-NUP96
- Nup
- Nup 96
- Nup 98
- Nup-98
- Nup96
- Nup96-98
- Nup98
- Nup98-Nup96
- Nup98/96
- l(3)95BCd
- nup145
- nup98
- nup98-96
- nucleoporin 98-96kD
- CG10198-PA
- CG10198-PC
- CG10198-PD
- Nup98
- Nup98-96-PA
- Nup98-96-PC
- Nup98-96-PD
- nucleoporin 96
- nucleoporin 98
- nucleoporin 98-96
- nucleoporin98-96
Part of the nuclear pore complex (NPC) (PMID: 25197089). Required for MAD import as part of the Nup107-160 complex and required for nuclear export of Moe probably via its association with Rae1 (PMID: 20547758, PMID: 28554770). Plays a role in nuclear mRNA export (PMID: 28554770). Promotes cell antiviral response by up-regulating FoxK-dependent antiviral gene transcription (PMID: 25197089, PMID: 25852164). In germline stem cells, involved in their maintenance and division together with the TGF-Beta and EGFR signaling pathways (PMID: 21949861). In larval lymph glands, has a role in the maintenance of hematopoiesis by regulating Pvr expression (PMID: 25201876).
Part of the nuclear pore complex (NPC) (PMID: 25310983). In the nucleoplasm, binds to transcriptionally active chromatin with a preference for regulatory regions; co-localizes with RNA polymerase II in a RNA-independent manner and before transition into transcription elongation (PMID: 20144760, PMID: 20144761, PMID: 28366641). Plays a role in the transcriptional memory process by stabilizing enhancer-promoter loops and by mediating anchoring of chromatin to the nuclear pore complex region (PMID: 28366641). During larval development, interacts with trx and MBD-R2 and regulates transcription of developmental genes including ecdysone-responsive genes such as Eip74 and E23 (PMID: 20144761, PMID: 25310983, PMID: 28366641).
Part of the nuclear pore complex (NPC).
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