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RECK - reversion inducing cysteine rich protein with kazal motifs (chicken)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-10
Description
Please note that currently there is no data available in PubChem associated with RECK - reversion inducing cysteine rich protein with kazal motifs (chicken). However, annotations from external sources are available.

1 Names and Identifiers

1.1 Synonyms

reversion-inducing cysteine-rich protein with Kazal motifs

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Bgee Gene ID

1.2.3 GlyCosmos Gene

1.2.4 VEuPathDB ID

3 Proteins

3.1 Protein Function

Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (By similarity). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. Also acts as a serine protease inhibitor (By similarity).

3.2 Protein Targets

4 Interactions and Pathways

4.1 Interactions

5 Literature

5.1 Gene-Chemical Co-Occurrences in Literature

5.2 Gene-Gene Co-Occurrences in Literature

5.3 Gene-Disease Co-Occurrences in Literature

6 Information Sources

CONTENTS