alpha-Man-IIa - alpha-Mannosidase class II a (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
Enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity. Involved in N-glycan processing; encapsulation of foreign target; and rhodopsin biosynthetic process. Located in Golgi membrane. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to several human genes including MAN2A2 (mannosidase alpha class 2A member 2).
- CG18474
- CG18802
- CG8139
- DM-GII.1
- Dmel\CG18802
- GMII
- GmII
- MAN-2
- Man
- Man-II
- agr;-Man-II
- alpha-Man-II
- alpha-Man-IIA
- alpha-Man-IIalpha
- dGMII
- dGMIIb
- CG18802-PA
- CG18802-PB
- alpha mannosidase II
- alpha-Man-IIa-PA
- alpha-Man-IIa-PB
- alpha-mannosidase 2
- alpha-mannosidase II
- alpha-mannosidase-II
- chain A, golgi Alpha-Mannosidase Ii
- golgi Man II
- golgi alpha-mannosidase
- golgi alpha-mannosidase II
- golgi mannosidase II
- mannosidase II
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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