Coq2 - Coenzyme Q biosynthesis protein 2 (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-15
Description
Predicted to enable 4-hydroxybenzoate polyprenyltransferase activity. Involved in defense response to other organism and determination of adult lifespan. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head; embryonic/larval midgut; indirect flight muscle cell; and organism. Used to study nephrotic syndrome and primary coenzyme Q10 deficiency 1. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 1. Orthologous to human COQ2 (coenzyme Q2, polyprenyltransferase).
- CG9613
- COQ2
- Dmel\CG9613
- coq2
- sbo
- coenzyme Q biosynthesis protein 2
- CG9613-PA
- Coq2-PA
- small boy
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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