Nep2 - Neprilysin 2 (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
Enables metalloendopeptidase activity. Involved in proteolysis and sperm competition. Located in extracellular space. Is expressed in several structures, including adult brain; epithelium; follicle cell; synaptic neuropil domain; and visceral trunk mesoderm derivative. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1).
- BcDNA:GH07643
- CG9761
- DmNEP2
- Dmel\CG9761
- NEP2
- dNEP2
- nep2
- neprilysin 2
- CG9761-PA
- CG9761-PB
- CG9761-PC
- Nep2-PA
- Nep2-PB
- Nep2-PC
- neprilysin-2
Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues (PMID: 15554877, PMID: 17157960). Functions in female fertility, embryogenesis and memory formation (PMID: 24395329, PMID: 27629706). Required in females for normal patterns of egg laying, probably due to its function in sperm retention and preventing sperm displacement by rival ejaculates (PMID: 24395329). Also required for normal patterns of hatching due to its important role in early embryonic development (PMID: 24395329). Required in the dorsal paired medial neurons for the proper formation of middle-term memory (PMID: 27629706). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep3 and Nep4 in normal long-term memory formation (PMID: 27629706).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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