Spn77Ba - Serpin 77Ba (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in negative regulation of melanization defense response. Located in extracellular space. Is expressed in adult head; embryonic/larval gut; epithelium; and imaginal disc. Human ortholog(s) of this gene implicated in thrombophilia. Orthologous to human SERPINA10 (serpin family A member 10).
- CG6680
- Dmel\CG6680
- Q0E8C8_DROME
- l(3)77ABi
- spn77Ba
- serpin 77Ba
- CG6680-PA
- CG6680-PB
- CG6680-PC
- Spn77Ba-PA
- Spn77Ba-PB
- Spn77Ba-PC
- lethal (3) 77ABi
Serine protease inhibitor which plays an essential role in regulating the tracheal melanization immune response to bacterial and fungal infection (PMID: 18854145, PMID: 22227521). Acts by negatively regulating a protease cascade involving Mp1 and Sp7, that functions in the activation of the Hayan-phenoloxidase (PPO1) cascade (PMID: 18854145).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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