LanA - Laminin A (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
Predicted to be an extracellular matrix structural constituent. Involved in several processes, including dorsal trunk growth, open tracheal system; melanotic encapsulation of foreign target; and negative regulation of synaptic assembly at neuromuscular junction. Located in basement membrane and presynaptic periactive zone. Is expressed in several structures, including embryonic/larval midgut primordium; germ layer; glial cell; head epidermis primordium; and hemocyte. Human ortholog(s) of this gene implicated in bent bone dysplasia syndrome 2; familial nephrotic syndrome; junctional epidermolysis bullosa; and lung small cell carcinoma. Orthologous to several human genes including LAMA5 (laminin subunit alpha 5).
- 5]]
- CG10236
- CT28769
- Dmel\CG10236
- FBgn0002526
- FBtr0077014
- LM-A/alpha1
- LMalpha1
- Lam
- Lam-A
- LamA
- Laminin
- Lan
- alpha3/5
- alpha[[3
- hdln
- lamA
- laminin alpha3/5
- lanA
- laminin A
- CG10236-PA
- LanA-PA
- alpha3,5 laminin
- headline
- laminin
- laminin A chain
- laminin A subunit
- laminin A5
- laminin alpha
- laminin alpha-chain
- laminin alpha3,5
- laminin alpha[[3,5]]
- lamininA
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Activates presynaptic signaling involving integrin alpha-PS3/beta-nu and Fak to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with integrin alpha-PS3/beta-nu, glutamate receptor-modulated NMJ growth.
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