Fitm - Fat storage inducing transmembrane protein (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Predicted to enable coenzyme A diphosphatase activity. Involved in several processes, including adult locomotory behavior; regulation of dendrite development; and sensory perception of sound. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Used to study Siddiqi syndrome and lipid metabolism disorder. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to several human genes including FITM2 (fat storage inducing transmembrane protein 2).
- CG10671
- Dmel\CG10671
- FIT2
- i136
- CG10671-PA
- CG10671-PB
- Fitm-PA
- Fitm-PB
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity) (PMID: 28067622). May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity) (PMID: 28067622). Required for correct morphology of nociceptive multi-dendritic sensory neurons (PMID: 28067622). Required for normal mechanical amplification in hearing (PMID: 28067622).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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