sotv - sister of tout-velu (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Involved in chondroitin sulfate biosynthetic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; and heparin biosynthetic process. Located in Golgi apparatus and endoplasmic reticulum. Part of EXT1-EXT2 complex. Is expressed in adult ensheathing glial cell and organism. Orthologous to human EXT2 (exostosin glycosyltransferase 2).
- BcDNA:GH02288
- CG33038
- CG8433
- DEXT2
- DExt2
- Dmel\CG8433
- EXT2
- Ext2
- Sotv
- dExt2
- CG8433-PB
- Ext2
- sister of ttv
- sister-of-tout-velu
- sotv-PB
- sotv (Eupeodes corollae)
- sotv (Uloborus diversus)
- sotv (mosquito)
- sotv (Leptopilina boulardi)
- sotv (Chinese mitten crab)
- sotv (Leptidea sinapis)
- sotv (Bombus affinis)
- sotv (spruce gall adelgid)
- sotv (European peacock)
- sotv (Anthonomus grandis grandis)
- sotv (pink bollworm)
- sotv (desert locust)
- sotv (African malaria mosquito)
- sotv (Pieris napi)
- sotv (fleshy prawn)
- sotv (corn earworm)
- sotv (painted lady)
- sotv (American house dust mite)
- sotv (European hornet)
- sotv (Diprion similis)
- sotv (Neodiprion virginianus)
- sotv (white pine sawfly)
- sotv (Neodiprion fabricii)
- sotv (Ischnura elegans)
- sotv (meadow brown)
- sotv (red swamp crayfish)
- sotv (large cabbage white)
- sotv (clouded yellow)
- sotv (Glanville fritillary)
- sotv (swimming crab)
- sotv (seven-spotted ladybird)
- sotv (Chrysoperla carnea)
- sotv (Cotesia glomerata)
- sotv (Aphidius gifuensis)
- sotv (Himalayan honeybee)
- sotv (western yellowjacket)
- sotv (Bombus pyrosoma)
- sotv (Frieseomelitta varia)
- sotv (common paper wasp)
- sotv (Leptopilina heterotoma)
- sotv (Venturia canescens)
- sotv (Colletes gigas)
- sotv (Penaeus japonicus)
- sotv (American lobster)
- sotv (Anopheles merus)
- sotv (salmon louse)
- sotv (Anopheles coluzzii)
- sotv (Anopheles arabiensis)
- sotv (northern house mosquito)
- sotv (dogface butterfly)
- sotv (Teleopsis dalmanni)
- sotv (black soldier fly)
- sotv (common green bottle fly)
- sotv (black tiger shrimp)
- sotv (Dermacentor silvarum)
- sotv (brown dog tick)
- sotv (southern cattle tick)
- sotv (Bradysia coprophila)
- sotv (Asian malaria mosquito)
- sotv (Anopheles albimanus)
- sotv (Stegodyphus dumicola)
- sotv (Chelonus insularis)
- sotv (Thrips palmi)
- sotv (Bombus vosnesenskii)
- sotv (Megalopta genalis)
- sotv (Bombus bifarius)
- sotv (Bombus vancouverensis nearcticus)
- sotv (Daphnia magna)
- sotv (Alkali bee)
- sotv (swede midge)
- sotv (rice weevil)
- sotv (tobacco hornworm)
- sotv (Formica exsecta)
- sotv (Osmia bicornis bicornis)
- sotv (Asian corn borer)
- sotv (wild silkworm)
- sotv (cotton aphid)
- sotv (Pacific white shrimp)
- sotv (European house dust mite)
- sotv (corn leaf aphid)
- sotv (cabbage looper)
- sotv (western flower thrips)
- sotv (squinting bush brown)
- sotv (Cryptotermes secundus)
- sotv (Eurytemora carolleeae)
- sotv (Australian sheep blowfly)
- sotv (bark scorpion)
- sotv (Drosophila hydei)
- sotv (Colorado potato beetle)
- sotv (Onthophagus taurus)
- sotv (Spodoptera litura)
- sotv (Varroa jacobsoni)
- sotv (honeybee mite)
- sotv (brown planthopper)
- sotv (cabbage white)
- sotv (Zootermopsis nevadensis)
- sotv (cotton bollworm)
- sotv (Drosophila serrata)
- sotv (Pseudomyrmex gracilis)
- sotv (small hive beetle)
- sotv (mountain pine beetle)
- sotv (Asian tiger mosquito)
- sotv (sweet potato whitefly)
- sotv (Asian longhorned beetle)
- sotv (emerald ash borer)
- sotv (Hyalella azteca)
- sotv (Drosophila navojoa)
- sotv (Ceratina calcarata)
- sotv (Drosophila arizonae)
- sotv (Nicrophorus vespilloides)
- sotv (snowberry fruit fly)
- sotv (Asiatic honeybee)
- sotv (common house spider)
- sotv (wheat stem sawfly)
- sotv (redheaded pine sawfly)
- sotv (Russian wheat aphid)
- sotv (Diachasma alloeum)
- sotv (Polistes canadensis)
- sotv (Dinoponera quadriceps)
- sotv (common yellow swallowtail)
- sotv (brown marmorated stink bug)
- sotv (bed bug)
- sotv (olive fruit fly)
- sotv (Atlantic horseshoe crab)
- sotv (Asian swallowtail)
- sotv (common Mormon)
- sotv (stable fly)
- sotv (pharaoh ant)
- sotv (Argentine ant)
- sotv (Atta cephalotes)
- sotv (Vollenhovia emeryi)
- sotv (red harvester ant)
- sotv (diamondback moth)
- sotv (Ceratosolen solmsi marchali)
- sotv (Fopius arisanus)
- sotv (Florida carpenter ant)
- sotv (red fire ant)
- sotv (Jerdon's jumping ant)
- sotv (Panamanian leafcutter ant)
- sotv (giant honeybee)
- sotv (house fly)
- sotv (domestic silkworm)
- sotv (Mediterranean fruit fly)
- sotv (little honeybee)
- sotv (common eastern bumble bee)
- sotv (buff-tailed bumblebee)
- sotv (pea aphid)
- sotv (jewel wasp)
- sotv (Drosophila willistoni)
- sotv (Drosophila virilis)
- sotv (Drosophila sechellia)
- sotv (Drosophila persimilis)
- sotv (Drosophila grimshawi)
- sotv (Drosophila erecta)
- sotv (Drosophila ananassae)
- sotv (yellow fever mosquito)
- sotv (Drosophila pseudoobscura)
- sotv (African malaria mosquito)
- sotv (honey bee)
- sotv (red flour beetle)
Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Plays a central role in diffusion of morphogens hedgehog (hh), wingless (wg) and Decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of Hh, Dpp and wg morphogens.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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