cora - coracle (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Predicted to enable actin binding activity and structural molecule activity. Involved in several processes, including adult somatic muscle development; cell adhesion involved in heart morphogenesis; and neurogenesis. Located in plasma membrane and smooth septate junction. Is expressed in several structures, including epidermis; epithelial cell; gut section; imaginal disc; and internal sense organ. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 11; esophagus squamous cell carcinoma; and hereditary elliptocytosis. Orthologous to several human genes including EPB41 (erythrocyte membrane protein band 4.1) and EPB41L1 (erythrocyte membrane protein band 4.1 like 1).
- CG11949
- COR
- Cor
- Cora
- Coracle
- D4.1
- Dmel\CG11949
- cor
- l(2)k08713
- mdcds_14526
- CG11949-PA
- CG11949-PB
- CG11949-PC
- CG11949-PE
- CG11949-PF
- CG11949-PG
- D4.1-Coracle
- cora-PA
- cora-PB
- cora-PC
- cora-PE
- cora-PF
- cora-PG
An integral component of the septate junction. May play a role in cell-cell interactions that are necessary for proper development. Vital for embryonic development.
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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