Pir - pirin (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-15
Description
Predicted to enable metal ion binding activity; quercetin 2,3-dioxygenase activity; and transcription coregulator activity. Predicted to be involved in monocyte differentiation. Predicted to act upstream of or within myeloid cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Orthologous to human PIR (pirin).
- pirin (iron-binding nuclear protein)
- probable quercetin 2,3-dioxygenase PIR
- probable quercetinase
Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro) (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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