RnrS - Ribonucleoside diphosphate reductase small subunit (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables cysteine-type endopeptidase activator activity involved in apoptotic process. Predicted to be involved in deoxyribonucleotide biosynthetic process. Predicted to be part of ribonucleoside-diphosphate reductase complex. Predicted to be active in cytosol. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; head epidermis primordium; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; mitochondrial DNA depletion syndrome 8b; and pancreatic cancer. Orthologous to several human genes including RRM2 (ribonucleotide reductase regulatory subunit M2).
- CG8975
- DmRNR2
- Dmel\CG8975
- R2
- RNR-S
- RNR2
- RNRS
- RNrS
- RnRs
- Rnr2
- Rnrs
- anon-WO0118547.148
- dRNR2
- rnr2
- rnrS
- ribonucleoside diphosphate reductase small subunit
- CG8975-PA
- RnrS-PA
- ribonucleoside-diphosphate reductase small subunit
- ribonucleotide reductase
- ribonucleotide reductase small subunit
Ribonucleotide Reductase
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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