Pnpla2 - patatin-like phospholipase domain containing 2 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Predicted to enable acylglycerol O-acyltransferase activity and carboxylic ester hydrolase activity. Predicted to be involved in several processes, including acylglycerol metabolic process; intracellular triglyceride homeostasis; and lipid droplet disassembly. Predicted to act upstream of with a negative effect on lipid droplet fusion. Predicted to act upstream of or within cellular lipid catabolic process and lipid droplet organization. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm; lipid droplet; and membrane. Orthologous to human PNPLA2 (patatin like phospholipase domain containing 2).
- RGD1309044
- patatin-like phospholipase domain-containing protein 2
- adipose triglyceride lipase
- calcium-independent phospholipase A2-zeta
- iPLA2-zeta
- patatin-like phospholipase domain-containing protein 2-like
- PNPLA2 (human)
- PNPLA2 (black-footed ferret)
- PNPLA2 (European mink)
- PNPLA2 (Ahaetulla prasina)
- PNPLA2 (red-backed fairy wren)
- PNPLA2 (Oenanthe melanoleuca)
- PNPLA2 (Chinese forest musk deer)
- PNPLA2 (raccoon dog)
- PNPLA2 (Leopard gecko)
- PNPLA2 (Pteronotus mesoamericanus)
- PNPLA2 (black-legged kittiwake)
- PNPLA2 (Aeolian wall lizard)
- PNPLA2 (graceful crag lizard)
- PNPLA2 (lesser prairie-chicken)
- PNPLA2 (takin)
- PNPLA2 (yellow-footed antechinus)
- PNPLA2 (rabbit)
- PNPLA2 (California condor)
- PNPLA2 (Macaca thibetana thibetana)
- PNPLA2 (Northern goshawk)
- PNPLA2 (snow leopard)
- PNPLA2 (rock ptarmigan)
- PNPLA2 (Loggerhead turtle)
- PNPLA2 (Sphaerodactylus townsendi)
- PNPLA2 (Eurasian river otter)
- PNPLA2 (bobcat)
- PNPLA2 (greater spear-nosed bat)
- PNPLA2 (American black bear)
- PNPLA2 (Ring-tailed lemur)
- PNPLA2 (Komodo dragon)
- PNPLA2 (Asiatic toad)
- PNPLA2 (American mink)
- PNPLA2 (leopard cat)
- PNPLA2 (wapiti)
- PNPLA2 (fence lizard)
- PNPLA2 (Arctic fox)
- PNPLA2 (rufous-necked snowfinch)
- PNPLA2 (white-rumped snowfinch)
- PNPLA2 (jaguarundi)
- PNPLA2 (common toad)
- PNPLA2 (common frog)
- PNPLA2 (scimitar-horned oryx)
- PNPLA2 (Barn swallow)
- PNPLA2 (large flying fox)
- PNPLA2 (Eurasian tree sparrow)
- PNPLA2 (Reeves's turtle)
- PNPLA2 (Tiger rattlesnake)
- PNPLA2 (striped hyena)
- PNPLA2 (leatherback sea turtle)
- PNPLA2 (Iberian mole)
- PNPLA2 (Jamaican fruit-eating bat)
- PNPLA2 (Sturnira hondurensis)
- PNPLA2 (Kuhl's pipistrelle)
- PNPLA2 (Myotis myotis)
- PNPLA2 (Pallas's mastiff bat)
- PNPLA2 (black swan)
- PNPLA2 (common lizard)
- PNPLA2 (Southern elephant seal)
- PNPLA2 (Trachemys scripta elegans)
- PNPLA2 (Pantherophis guttatus)
- PNPLA2 (Gaboon caecilian)
- PNPLA2 (Francois's langur)
- PNPLA2 (greater horseshoe bat)
- PNPLA2 (Abingdon island giant tortoise)
- PNPLA2 (vaquita)
- PNPLA2 (tufted duck)
- PNPLA2 (silvery gibbon)
- PNPLA2 (ring-necked pheasant)
- PNPLA2 (Kakapo)
- PNPLA2 (Microcaecilia unicolor)
- PNPLA2 (Aquila chrysaetos chrysaetos)
- PNPLA2 (Common wall lizard)
- PNPLA2 (pale spear-nosed bat)
- PNPLA2 (Steller sea lion)
- PNPLA2 (willow flycatcher)
- PNPLA2 (California sea lion)
- PNPLA2 (burrowing owl)
- PNPLA2 (eastern brown snake)
- PNPLA2 (mainland tiger snake)
- PNPLA2 (brown bear)
- PNPLA2 (emu)
- PNPLA2 (Okarito brown kiwi)
- PNPLA2 (Nothoprocta perdicaria)
- PNPLA2 (red fox)
- PNPLA2 (puma)
- PNPLA2 (dingo)
- PNPLA2 (gelada)
- PNPLA2 (Yangtze finless porpoise)
- PNPLA2 (common vampire bat)
- PNPLA2 (blue tit)
- PNPLA2 (Ugandan red Colobus)
- PNPLA2 (beluga whale)
- PNPLA2 (Hawaiian monk seal)
- PNPLA2 (white-rumped munia)
- PNPLA2 (helmeted guineafowl)
- PNPLA2 (koala)
- PNPLA2 (central bearded dragon)
- PNPLA2 (great roundleaf bat)
- PNPLA2 (Australian saltwater crocodile)
- PNPLA2 (Gharial)
- PNPLA2 (leopard)
- PNPLA2 (Nanorana parkeri)
- PNPLA2 (black snub-nosed monkey)
- PNPLA2 (Malayan pangolin)
- PNPLA2 (Panamanian white-faced capuchin)
- PNPLA2 (Miniopterus natalensis)
- PNPLA2 (Egyptian rousette)
- pnpla2 (turquoise killifish)
- PNPLA2 (Japanese quail)
- PNPLA2 (Taiwan habu)
- PNPLA2 (Great Tit)
- PNPLA2 (Gekko japonicus)
- PNPLA2 (cheetah)
- PNPLA2 (Common starling)
- PNPLA2 (ass)
- PNPLA2 (Thamnophis sirtalis)
- PNPLA2 (North Island brown kiwi)
- PNPLA2 (Swan goose)
- PNPLA2 (gray mouse lemur)
- PNPLA2 (Coquerel's sifaka)
- PNPLA2 (sooty mangabey)
- PNPLA2 (drill)
- PNPLA2 (Colobus angolensis palliatus)
- PNPLA2 (pig-tailed macaque)
- PNPLA2 (large flying fox)
- PNPLA2 (Arabian camel)
- PNPLA2 (Bactrian camel)
- PNPLA2 (Bison bison bison)
- PNPLA2 (bald eagle)
- PNPLA2 (Corvus cornix cornix)
- PNPLA2 (golden snub-nosed monkey)
- PNPLA2 (East African grey crowned-crane)
- PNPLA2 (white-throated tinamou)
- PNPLA2 (speckled mousebird)
- PNPLA2 (chuck-will's-widow)
- PNPLA2 (sunbittern)
- PNPLA2 (Buceros rhinoceros silvestris)
- PNPLA2 (Macqueen's bustard)
- PNPLA2 (yellow-throated sandgrouse)
- PNPLA2 (Kea)
- PNPLA2 (chimney swift)
- PNPLA2 (red-crested turaco)
- PNPLA2 (common barn owl)
- PNPLA2 (cuckoo roller)
- PNPLA2 (hoatzin)
- PNPLA2 (white-tailed eagle)
- PNPLA2 (Downy woodpecker)
- PNPLA2 (killdeer)
- PNPLA2 (bar-tailed trogon)
- PNPLA2 (red-throated loon)
- PNPLA2 (Red-legged seriema)
- PNPLA2 (African ostrich)
- PNPLA2 (little egret)
- PNPLA2 (Northern fulmar)
- PNPLA2 (common cuckoo)
- PNPLA2 (Dalmatian pelican)
- PNPLA2 (crested ibis)
- PNPLA2 (Adelie penguin)
- PNPLA2 (emperor penguin)
- PNPLA2 (Common canary)
- PNPLA2 (rifleman)
- PNPLA2 (polar bear)
- PNPLA2 (American crow)
- PNPLA2 (Sunda flying lemur)
- PNPLA2 (Przewalski's horse)
- PNPLA2 (big brown bat)
- PNPLA2 (Philippine tarsier)
- PNPLA2 (green monkey)
- PNPLA2 (platypus)
- PNPLA2 (Yangtze River dolphin)
- PNPLA2 (Burmese python)
- PNPLA2 (minke whale)
- PNPLA2 (sperm whale)
- PNPLA2 (tiger)
- PNPLA2 (Green sea turtle)
- PNPLA2 (black flying fox)
- PNPLA2 (Myotis davidii)
- PNPLA2 (Weddell seal)
- PNPLA2 (American alligator)
- PNPLA2 (alpaca)
- PNPLA2 (Wild Bactrian camel)
- PNPLA2 (Chinese tree shrew)
- PNPLA2 (Chinese soft-shelled turtle)
- PNPLA2 (water buffalo)
- PNPLA2 (Chinese alligator)
- PNPLA2 (coelacanth)
- PNPLA2 (wild yak)
- PNPLA2 (Brandt's bat)
- PNPLA2 (crab-eating macaque)
- PNPLA2 (Tibetan ground-tit)
- PNPLA2 (rock pigeon)
- PNPLA2 (white-throated sparrow)
- PNPLA2 (Saker falcon)
- PNPLA2 (medium ground-finch)
- Pnpla2 (long-tailed chinchilla)
- PNPLA2 (western painted turtle)
- PNPLA2 (peregrine falcon)
- pnpla2 (zebrafish)
- PNPLA2 (Collared flycatcher)
- PNPLA2 (mallard)
- PNPLA2 (domestic ferret)
- PNPLA2 (small Madagascar hedgehog)
- PNPLA2 (European shrew)
- PNPLA2 (nine-banded armadillo)
- PNPLA2 (Pacific walrus)
- PNPLA2 (killer whale)
- PNPLA2 (western lowland gorilla)
- PNPLA2 (sheep)
- PNPLA2 (domestic cat)
- PNPLA2 (Bolivian squirrel monkey)
- PNPLA2 (olive baboon)
- PNPLA2 (pygmy chimpanzee)
- PNPLA2 (small-eared galago)
- PNPLA2 (Tasmanian devil)
- PNPLA2 (goat)
- PNPLA2 (African savanna elephant)
- PNPLA2 (northern white-cheeked gibbon)
- PNPLA2 (giant panda)
- PNPLA2 (Sumatran orangutan)
- PNPLA2 (white-tufted-ear marmoset)
- PNPLA2 (turkey)
- PNPLA2 (zebra finch)
- PNPLA2 (horse)
- PNPLA2 (pig)
- PNPLA2 (gray short-tailed opossum)
- pnpla2 (tropical clawed frog)
- PNPLA2 (Rhesus monkey)
- PNPLA2 (dog)
- PNPLA2 (domestic cattle)
- PNPLA2 (chimpanzee)
- PNPLA2 (chicken)
- Pnpla2 (house mouse)
Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (By similarity). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (By similarity). Regulates adiposome size and may be involved in the degradation of adiposomes (By similarity). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (By similarity). Acts antagonistically with LDAH in regulation of cellular lipid stores (By similarity). Inhibits LDAH-stimulated lipid droplet fusion (By similarity). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
- NCBI GeneLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- PubChem
- Alliance of Genome ResourcesLICENSEAll annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).https://www.alliancegenome.org/privacy-warranty-licensing
- BioGRIDLICENSEThe MIT License (MIT); Copyright Mike Tyers Labhttps://wiki.thebiogrid.org/doku.php/terms_and_conditions
- STRING: functional protein association networks
- GlyCosmos Glycoscience PortalLICENSEAll copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.https://glycosmos.org/license
- NCBI Gene Expression Omnibus (GEO)
- Rat Genome Database (RGD)LICENSECreative Commons Attribution 4.0 International license (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
- Swiss Institute of Bioinformatics Bgee
- UniProtLICENSEWe have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.https://www.uniprot.org/help/license
- Wikidata
- AlphaFold DBLICENSEAll of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.https://alphafold.ebi.ac.uk/faq
- Rhea - annotated reactions databaseLICENSERhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.https://www.rhea-db.org/help/license-disclaimer
CONTENTS