Brca2 - BRCA2, DNA repair associated (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-14
Description
Enables single-stranded DNA binding activity. Involved in several processes, including homologous chromosome orientation in meiotic metaphase I; response to estradiol; and spermatogenesis. Predicted to be located in several cellular components, including centrosome; chromosome, telomeric region; and nuclear lumen. Predicted to be part of BRCA2-MAGE-D1 complex; DNA repair complex; and nuclear ubiquitin ligase complex. Predicted to be active in nucleus. Used to study atrophy of testis; cancer; cataract; infertility; and osteosarcoma. Biomarker of ductal carcinoma in situ and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); esophagus squamous cell carcinoma; hereditary breast ovarian cancer syndrome; melanoma (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA2 (BRCA2 DNA repair associated).
- breast cancer type 2 susceptibility protein homolog
- breast cancer 2, early onset
- breast cancer 2, mutation 1, University of Wisconsin-Madison
- breast cancer susceptibility protein 2
- fanconi anemia group D1 protein homolog
- NCBI GeneLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- PubChem
- Alliance of Genome ResourcesLICENSEAll annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).https://www.alliancegenome.org/privacy-warranty-licensing
- NCBI StructureLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- Rat Genome Database (RGD)LICENSECreative Commons Attribution 4.0 International license (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
- Wikidata
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