An official website of the United States government

CadN - Cadherin-N (fruit fly)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-17
Description
Enables cadherin binding activity; calcium ion binding activity; and protein homodimerization activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and neuron development. Located in several cellular components, including axon; cell-cell junction; and dendrite. Is expressed in several structures, including mushroom body; neuron projection bundle; organism subdivision; synaptic neuropil domain; and synaptic neuropil layer. Used to study prostate cancer.

1 Names and Identifiers

1.1 Synonyms

  • B
  • CG7100
  • CT21941
  • Cad-N
  • D-cad
  • DN
  • DN-CAD
  • DN-CAd
  • DN-Cad
  • DN-cad
  • DN-cadherin
  • DNCad
  • DNcad
  • Dmel\CG7100
  • N-Cad
  • N-Cadh
  • N-Cadherin
  • N-cad
  • N-cadherin
  • NCAD
  • NCad
  • Ncad
  • S(DmcycE[JP])2.12
  • anon-EST:CL32
  • cad1
  • cadN
  • l(2)36Da
  • l(2)Bld
  • n-cad
  • ncad
  • CG7100-PA
  • CG7100-PB
  • CG7100-PC
  • CG7100-PD
  • CG7100-PE
  • CG7100-PF
  • CG7100-PG
  • CG7100-PH
  • CG7100-PI
  • CG7100-PJ
  • CG7100-PK
  • CG7100-PL
  • CadN-PA
  • CadN-PB
  • CadN-PC
  • CadN-PD
  • CadN-PE
  • CadN-PF
  • CadN-PG
  • CadN-PH
  • CadN-PI
  • CadN-PJ
  • CadN-PK
  • CadN-PL
  • CadherinN
  • DN cadherin
  • DN-cadherin
  • DN-cadherin, N-cadherin
  • DN-cadherin1
  • drosophila neuronal cadherin
  • lethal(2)36Da
  • n-cadherin
  • nCadherin

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 FlyBase ID

1.2.5 VEuPathDB ID

1.2.6 Wikidata

2 Proteins

2.1 Protein Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information.

2.2 Protein Isoforms

Isoform
Isoform D
UniProt ID
RefSeq Accession
Isoform
Isoform A
UniProt ID
RefSeq Accession
Isoform
Isoform B
UniProt ID
RefSeq Accession
Isoform
Isoform C
UniProt ID
RefSeq Accession
Isoform
Isoform E
UniProt ID
RefSeq Accession
Isoform
Isoform F
UniProt ID
RefSeq Accession
Isoform
Isoform G
UniProt ID
RefSeq Accession
Isoform
Isoform H
UniProt ID
RefSeq Accession

2.3 Protein 3D Structures

2.3.1 PDB Structures

2.3.2 NCBI Protein Structures

2.4 Protein Targets

3 BioAssays

3.1 RNAi BioAssays

4 Interactions and Pathways

4.1 Chemical-Gene Interactions

4.2 Interactions

5 Expression

6 Literature

6.1 Consolidated References

6.2 Gene-Chemical Co-Occurrences in Literature

6.3 Gene-Gene Co-Occurrences in Literature

6.4 Gene-Disease Co-Occurrences in Literature

7 Patents

8 Classification

8.1 Gene Ontology: Biological Process

8.2 Gene Ontology: Cellular Component

8.3 Gene Ontology: Molecular Function

9 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. STRING: functional protein association networks
  6. Comparative Toxicogenomics Database (CTD)
    LICENSE
    It is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.
    http://ctdbase.org/about/legal.jsp
  7. FlyBase
    LICENSE
    All annotations and data produced by FlyBase that are accessible from flybase.org are distributed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
    https://wiki.flybase.org/wiki/FlyBase:About#FlyBase_Licenses_and_Availability
  8. NCBI Gene Expression Omnibus (GEO)
  9. NCBI Structure
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  10. RCSB Protein Data Bank (RCSB PDB)
    LICENSE
    Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.
    https://www.rcsb.org/pages/policies
  11. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  12. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  13. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  14. Wikidata
  15. Gene Ontology (GO)
    LICENSE
    Gene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)
    http://geneontology.org/docs/go-citation-policy/
CONTENTS