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CycE - Cyclin E (fruit fly)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-26
Description
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including G1/S transition of mitotic cell cycle; nervous system development; and regulation of mitotic cell cycle phase transition. Located in nucleus. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; gut section; head epidermis primordium; and stem cell. Used to study cancer and prostate cancer. Human ortholog(s) of this gene implicated in breast adenocarcinoma and castration-resistant prostate carcinoma. Orthologous to several human genes including CCNE2 (cyclin E2).

1 Names and Identifiers

1.1 Synonyms

  • 3938
  • BG:DS07108.3
  • CDI7
  • CG3938
  • CYCE
  • Cdi7
  • CyE-1
  • Cyc
  • Cyc E
  • Cyc-E
  • CycEI
  • CyclE
  • CyeE
  • D-CycE
  • DmCycE
  • DmcycE
  • DmcyclinE
  • Dmel\CG3938
  • br37
  • cdi7
  • cycE
  • cyclin E
  • cyclin-E
  • cyclinE
  • cycline
  • dCycE
  • dm-cycE
  • fond
  • l(2)05206
  • l(2)35Dd
  • l(2)br37
  • l(2)k02514
  • l(2)k02602
  • l(2)k05007
  • l35Dd
  • cyclin E
  • CG3938-PA
  • CG3938-PB
  • CG3938-PC
  • CG3938-PD
  • CG3938-PE
  • CG3938-PF
  • CycE-PA
  • CycE-PB
  • CycE-PC
  • CycE-PD
  • CycE-PE
  • CycE-PF
  • Cyclin-dependent kinase interactor 7
  • cyclin
  • cyclin-E
  • cyclinE
  • cycline E
  • dCyclinE
  • fondue

1.1.1 MeSH Entry Terms

Cyclin

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 FlyBase ID

1.2.5 VEuPathDB ID

1.2.6 Wikidata

2 Proteins

2.1 Protein Function

Essential for the control of the cell cycle at the G1/S (start) transition. Targeted by archipelago for degradation by the SFC ubiquitin ligase complex.

2.2 Protein Isoforms

Isoform
Isoform II
UniProt ID
RefSeq Accession
Isoform
Isoform II
UniProt ID
RefSeq Accession
Isoform
Isoform II
UniProt ID
RefSeq Accession
Isoform
Isoform II
UniProt ID
RefSeq Accession
Isoform
Isoform I
UniProt ID
RefSeq Accession

2.3 Protein 3D Structures

2.3.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.4 Protein Targets

3 BioAssays

3.1 RNAi BioAssays

4 Diseases and Phenotypes

4.1 Gene-Disease Associations

5 Interactions and Pathways

5.1 Chemical-Gene Interactions

5.2 Interactions

5.3 Pathways

6 Biochemical Reactions

7 Expression

8 Literature

8.1 Consolidated References

8.2 NLM Curated PubMed Citations

8.3 Gene-Chemical Co-Occurrences in Literature

8.4 Gene-Gene Co-Occurrences in Literature

8.5 Gene-Disease Co-Occurrences in Literature

9 Patents

10 Classification

10.1 MeSH Tree

10.2 Gene Ontology: Biological Process

10.3 Gene Ontology: Cellular Component

10.4 Gene Ontology: Molecular Function

11 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  4. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  5. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  6. Database of Interacting Proteins (DIP)
    LICENSE
    All DIP database records available under the terms set by the Creative Commons Attribution-NoDerivs License.
    https://dip.doe-mbi.ucla.edu/dip/termsofuse.html
  7. STRING: functional protein association networks
  8. Comparative Toxicogenomics Database (CTD)
    LICENSE
    It is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.
    http://ctdbase.org/about/legal.jsp
  9. FlyBase
    LICENSE
    All annotations and data produced by FlyBase that are accessible from flybase.org are distributed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
    https://wiki.flybase.org/wiki/FlyBase:About#FlyBase_Licenses_and_Availability
  10. NCBI Gene Expression Omnibus (GEO)
  11. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  12. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  13. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  14. Wikidata
  15. Gene Ontology (GO)
    LICENSE
    Gene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)
    http://geneontology.org/docs/go-citation-policy/
  16. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
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