CycE - Cyclin E (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-26
Description
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including G1/S transition of mitotic cell cycle; nervous system development; and regulation of mitotic cell cycle phase transition. Located in nucleus. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; gut section; head epidermis primordium; and stem cell. Used to study cancer and prostate cancer. Human ortholog(s) of this gene implicated in breast adenocarcinoma and castration-resistant prostate carcinoma. Orthologous to several human genes including CCNE2 (cyclin E2).
- 3938
- BG:DS07108.3
- CDI7
- CG3938
- CYCE
- Cdi7
- CyE-1
- Cyc
- Cyc E
- Cyc-E
- CycEI
- CyclE
- CyeE
- D-CycE
- DmCycE
- DmcycE
- DmcyclinE
- Dmel\CG3938
- br37
- cdi7
- cycE
- cyclin E
- cyclin-E
- cyclinE
- cycline
- dCycE
- dm-cycE
- fond
- l(2)05206
- l(2)35Dd
- l(2)br37
- l(2)k02514
- l(2)k02602
- l(2)k05007
- l35Dd
- cyclin E
- CG3938-PA
- CG3938-PB
- CG3938-PC
- CG3938-PD
- CG3938-PE
- CG3938-PF
- CycE-PA
- CycE-PB
- CycE-PC
- CycE-PD
- CycE-PE
- CycE-PF
- Cyclin-dependent kinase interactor 7
- cyclin
- cyclin-E
- cyclinE
- cycline E
- dCyclinE
- fondue
Cyclin
Essential for the control of the cell cycle at the G1/S (start) transition. Targeted by archipelago for degradation by the SFC ubiquitin ligase complex.
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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