Sirt1 - Sirtuin 1 (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables NAD-dependent histone deacetylase activity and transcription coactivator binding activity. Involved in several processes, including behavioral response to ethanol; determination of adult lifespan; and regulation of gene expression. Located in cytoplasm and nucleoplasm. Is expressed in several structures, including embryonic/larval garland cell; embryonic/larval salivary gland; germ band; larval central nervous system; and ventral nerve cord. Used to study alcohol use disorder and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1).
- BEST:LD38188
- CG5216
- D.mel1
- DSir2
- Dmel\CG5216
- SIR-2
- SIR2
- SIRT1
- Sir2
- Sir2L
- Sirt1/dSir2
- dSIR2
- dSir2
- dmSRT406
- dsir2
- l(2)05326
- sir2
- sirt1
- sirtuin 1
- CG5216-PA
- Sir2
- Sirt1-PA
- silent information regulator 2
- sirtuin 2
- Sirt1
- Silent Mating Type Information Regulation 2 Homolog 1
NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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