APLP1 - amyloid beta precursor like protein 1 (human)
- Create:2016-09-14
- Modify:2025-02-02
- APLP
- amyloid beta (A4) precursor-like protein 1
- amyloid precursor-like protein 1
- amyloid-like protein 1
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
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