goe - gone early (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
Involved in negative regulation of stem cell differentiation and oogenesis. Located in plasma membrane. Is expressed in several structures, including adult head; mesectoderm; mesectoderm anlage; midline primordium; and unpaired neurons. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1).
- BcDNA:LD21405
- CG9634
- Dmel\CG9634
- Nepl2
- CG9634-PA
- CG9634-PB
- CG9634-PC
- Neprilysin-like 2
- goe-PA
- goe-PB
- goe-PC
Plays a role in the ovary in limiting the number of primordial germ cells (PGCs) that develop directly into gametes, allowing them instead to enter the developmental pathway that produces germline stem cells (GSCs) from PGCs and ensuring lifelong production of gametes from these GSCs. Negatively regulates epidermal growth factor receptor (Egfr) signaling. Probably down-regulates EGFR signaling on intermingled cells, a type of somatic stromal cell which contacts PGCs, and the resultant low level of signaling limits the proportion of PGCs which start gametogenesis, maintaining them in an undifferentiated proliferative state.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- PubChem
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- BioGRIDLICENSEThe MIT License (MIT); Copyright Mike Tyers Labhttps://wiki.thebiogrid.org/doku.php/terms_and_conditions
- STRING: functional protein association networks
- FlyBaseLICENSEAll annotations and data produced by FlyBase that are accessible from flybase.org are distributed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).https://wiki.flybase.org/wiki/FlyBase:About#FlyBase_Licenses_and_Availability
- NCBI Gene Expression Omnibus (GEO)
- Swiss Institute of Bioinformatics Bgee
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- Wikidata
- Gene Ontology (GO)LICENSEGene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)http://geneontology.org/docs/go-citation-policy/Biological Processhttp://www.geneontology.org/
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