eag - ether a go-go (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2024-12-17
Description
Enables transmembrane transporter binding activity and voltage-gated potassium channel activity. Involved in learning and perineurial glial growth. Located in plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in adult head. Used to study epilepsy. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and developmental and epileptic encephalopathy. Orthologous to human KCNH1 (potassium voltage-gated channel subfamily H member 1) and KCNH5 (potassium voltage-gated channel subfamily H member 5).
- CG10952
- CIKE
- Dmel\CG10952
- EAG
- Eag
- CG10952-PA
- CG10952-PB
- CG10952-PC
- CG10952-PD
- CG10952-PE
- CG10952-PF
- CG10952-PG
- eag-PA
- eag-PB
- eag-PC
- eag-PD
- eag-PE
- eag-PF
- eag-PG
- ether-a go-go
- ether-a-go-go
- ether-a-gogo
Structural component of a potassium channel. Mediates the potassium permeability of membranes; potassium current is regulated by CaMKII and CASK. Has a role in growth of the perineurial glial layer of the larval peripheral nerve.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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