Xpac - Xeroderma pigmentosum group A-like (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-19
Description
Predicted to enable damaged DNA binding activity. Involved in nucleotide-excision repair. Located in nucleus. Is expressed in several structures, including adult central nervous system; lamina; larval ventral nerve cord; muscle cell; and retina. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Orthologous to human XPA (XPA, DNA damage recognition and repair factor).
- CG6358
- DhR14
- DhXPA
- DmXPA
- Dmel\CG6358
- Dxpa
- EG:EG0007.8
- XPA
- XPAC
- XPA_DROME
- Xpa
- dmXPA
- dxpa
- xeroderma pigmentosum group A-like
- CG6358-PA
- Xpac-PA
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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