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Xpac - Xeroderma pigmentosum group A-like (fruit fly)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-19
Description
Predicted to enable damaged DNA binding activity. Involved in nucleotide-excision repair. Located in nucleus. Is expressed in several structures, including adult central nervous system; lamina; larval ventral nerve cord; muscle cell; and retina. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Orthologous to human XPA (XPA, DNA damage recognition and repair factor).

1 Names and Identifiers

1.1 Synonyms

  • CG6358
  • DhR14
  • DhXPA
  • DmXPA
  • Dmel\CG6358
  • Dxpa
  • EG:EG0007.8
  • XPA
  • XPAC
  • XPA_DROME
  • Xpa
  • dmXPA
  • dxpa
  • xeroderma pigmentosum group A-like
  • CG6358-PA
  • Xpac-PA

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 FlyBase ID

1.2.5 VEuPathDB ID

1.2.6 Wikidata

2 Proteins

2.1 Protein Function

Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity).

2.2 Protein 3D Structures

2.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 BioAssays

3.1 RNAi BioAssays

4 Interactions and Pathways

4.1 Chemical-Gene Interactions

4.2 Interactions

4.3 Pathways

5 Biochemical Reactions

6 Expression

7 Literature

7.1 Consolidated References

7.2 Gene-Chemical Co-Occurrences in Literature

7.3 Gene-Gene Co-Occurrences in Literature

7.4 Gene-Disease Co-Occurrences in Literature

8 Patents

9 Classification

9.1 Gene Ontology: Biological Process

9.2 Gene Ontology: Cellular Component

9.3 Gene Ontology: Molecular Function

10 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. Database of Interacting Proteins (DIP)
    LICENSE
    All DIP database records available under the terms set by the Creative Commons Attribution-NoDerivs License.
    https://dip.doe-mbi.ucla.edu/dip/termsofuse.html
  6. STRING: functional protein association networks
  7. Comparative Toxicogenomics Database (CTD)
    LICENSE
    It is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.
    http://ctdbase.org/about/legal.jsp
  8. FlyBase
    LICENSE
    All annotations and data produced by FlyBase that are accessible from flybase.org are distributed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
    https://wiki.flybase.org/wiki/FlyBase:About#FlyBase_Licenses_and_Availability
  9. NCBI Gene Expression Omnibus (GEO)
  10. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  11. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  12. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  13. Wikidata
  14. Gene Ontology (GO)
    LICENSE
    Gene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)
    http://geneontology.org/docs/go-citation-policy/
  15. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
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