Trpa1 - transient receptor potential cation channel, subfamily A, member 1 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables osmolarity-sensing monoatomic cation channel activity and voltage-gated calcium channel activity. Involved in several processes, including cellular response to caffeine; cellular response to carbon dioxide; and positive regulation of transport. Located in apical plasma membrane and axon. Used to study asthma; diabetic neuropathy; and overactive bladder syndrome. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1).
- Anktm1
- transient receptor potential cation channel subfamily A member 1
- ankyrin-like with transmembrane domains protein 1
- wasabi receptor
Ligand-activated Ca(2+)-permeable, nonselective cation channel (PMID: 14712238, PMID: 18775987). Involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (By similarity). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm, leads to membrane depolarization. Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner. Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation. Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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