trr - trithorax-related (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2024-12-13
Description
Enables several functions, including core promoter sequence-specific DNA binding activity; histone H3K4 methyltransferase activity; and transcription coactivator activity. Involved in several processes, including positive regulation of ecdysone receptor signaling pathway; progression of morphogenetic furrow involved in compound eye morphogenesis; and response to ecdysone. Located in nucleus and polytene chromosome puff. Part of MLL3/4 complex. Is expressed in several structures, including embryonic/larval salivary gland; female germline cell; ganglia; gut section; and mesoderm. Used to study Kleefstra syndrome 2 and congenital heart disease. Human ortholog(s) of this gene implicated in Kabuki syndrome; Kleefstra syndrome 2; carcinoma (multiple); intracranial aneurysm; and stomach cancer (multiple). Orthologous to several human genes including KMT2D (lysine methyltransferase 2D).
- CG3848
- Dmel\CG3848
- EG:63B12.3
- TRR
- Trr
- anon-2Bb
- dmll3/4
- CG3848-PC
- CG3848-PD
- Trithorax-related
- Trx-related
- trithorax related
- trithorax-related protein
- trr-PC
- trr-PD
Histone methyltransferase that acts as a coactivator for the ecdysone receptor during development. Specifically trimethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation. Recruited by EcR in an ecdysone-dependent manner causing H3 'Lys-4' trimethylation at ecdysone-inducible promoters, leading to activate expression. Plays a central role in the developing compound eye, during the progression of the morphogenetic furrow and in post-furrow differentiation of the retinal epithelium, notably by activating expression of hh (PMID: 14603321, PMID: 23197473). Also required for wing and abdominal development (PMID: 14603321, PMID: 22726846, PMID: 23197473).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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