Mttp - microsomal triglyceride transfer protein (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables apolipoprotein binding activity and lipid transfer activity. Involved in several processes, including cholesterol homeostasis; lipoprotein metabolic process; and response to calcium ion. Located in basolateral plasma membrane; cell projection membrane; and vesicle. Biomarker of familial hyperlipidemia. Human ortholog(s) of this gene implicated in several diseases, including abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein).
- MTP
- microsomal triglyceride transfer protein large subunit
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PMID: 15897609, PMID: 16478722). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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