Sirt5 - sirtuin 5 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Predicted to enable NAD+ binding activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; and zinc ion binding activity. Involved in negative regulation of cardiac muscle cell apoptotic process and response to nutrient levels. Predicted to be located in cytosol; mitochondrial inner membrane; and mitochondrial intermembrane space. Predicted to be active in mitochondrial matrix. Orthologous to human SIRT5 (sirtuin 5).
- NAD-dependent protein deacylase sirtuin-5, mitochondrial
- NAD-dependent deacetylase sirtuin-5
- NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
- SIR2-like protein 5
- regulatory protein SIR2 homolog 5
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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