Abcg4 - ATP binding cassette subfamily G member 4 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-14
Description
Predicted to enable ABC-type sterol transporter activity; ATP hydrolysis activity; and protein dimerization activity. Predicted to be involved in several processes, including cholesterol efflux; cholesterol homeostasis; and positive regulation of cholesterol biosynthetic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in endosome membrane. Predicted to be active in plasma membrane. Orthologous to human ABCG4 (ATP binding cassette subfamily G member 4).
- ATP-binding cassette subfamily G member 4
- ATP-binding cassette sub-family G member 4
- ATP-binding cassette, sub-family G (WHITE), member 4
- ATP-binding cassette, subfamily G (WHITE), member 4
ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (By similarity). May play an important role in the removal of amyloid-beta peptides from brain,in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells (By similarity).
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