Nampt - nicotinamide phosphoribosyltransferase (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables several functions, including cytokine activity; identical protein binding activity; and nicotinamide phosphoribosyltransferase activity. Involved in several processes, including cellular response to amyloid-beta; microglial cell activation; and negative regulation of cellular senescence. Predicted to be located in cell junction; cytoplasm; and nuclear speck. Used to study middle cerebral artery infarction and transient cerebral ischemia. Biomarker of kidney failure; metabolic dysfunction-associated steatotic liver disease; periodontitis; and pulmonary hypertension. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase).
- Pbef
- Pbef1
- NAmPRTase
- pre-B-cell colony enhancing factor 1
- pre-B-cell colony-enhancing factor 1 homolog
- visfatin
- NAMPT Protein
- NAmPRTase
- NMN Pyrophosphorylase
- Pre-B-Cell Colony-Enhancing Factor
- Visfatin
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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