Gsn - gelsolin (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-19
Description
Enables actin binding activity. Involved in several processes, including actin filament depolymerization; oligodendrocyte development; and positive regulation of p38MAPK cascade. Located in several cellular components, including apical ectoplasmic specialization; basal ectoplasmic specialization; and cytoskeleton. Part of protein-containing complex. Biomarker of hypothyroidism; lung disease; and myocardial infarction. Human ortholog(s) of this gene implicated in Finnish type amyloidosis. Orthologous to human GSN (gelsolin).
- ADF
- actin-depolymerizing factor
- brevin
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (By similarity). Plays a role in ciliogenesis (By similarity).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- PubChem
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- STRING: functional protein association networks
- NCBI Gene Expression Omnibus (GEO)
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- Swiss Institute of Bioinformatics Bgee
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- Wikidata
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