Ggt5 - gamma-glutamyltransferase 5 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-15
Description
Predicted to enable glutathione hydrolase activity; leukotriene-C(4) hydrolase; and peptidyltransferase activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; glutathione catabolic process; and inflammatory response. Predicted to be active in plasma membrane. Orthologous to human GGT5 (gamma-glutamyltransferase 5).
- Ggta1
- Ggtla1
- glutathione hydrolase 5 proenzyme
- GGL
- GGT 5
- GGT-rel
- gamma-glutamyl leukotrienase
- gamma-glutamyl transpeptidase-related enzyme
- gamma-glutamyltransferase-like activity 1
- gamma-glutamyltranspeptidase 5
- leukotriene-C4 hydrolase
- GGT5 (human)
- GGT5 (black-footed ferret)
- GGT5 (European mink)
- GGT5 (Ahaetulla prasina)
- GGT5 (red-backed fairy wren)
- GGT5 (Oenanthe melanoleuca)
- GGT5 (Chinese forest musk deer)
- GGT5 (raccoon dog)
- GGT5 (Leopard gecko)
- GGT5 (Pteronotus mesoamericanus)
- GGT5 (black-legged kittiwake)
- GGT5 (Aeolian wall lizard)
- GGT5 (graceful crag lizard)
- GGT5 (lesser prairie-chicken)
- GGT5 (takin)
- GGT5 (yellow-footed antechinus)
- GGT5 (California condor)
- GGT5 (Macaca thibetana thibetana)
- GGT5 (Northern goshawk)
- GGT5 (snow leopard)
- GGT5 (rock ptarmigan)
- GGT5 (Loggerhead turtle)
- GGT5 (Sphaerodactylus townsendi)
- GGT5 (Eurasian river otter)
- GGT5 (bobcat)
- GGT5 (greater spear-nosed bat)
- GGT5 (American black bear)
- GGT5 (Ring-tailed lemur)
- GGT5 (Komodo dragon)
- GGT5 (Asiatic toad)
- GGT5 (American mink)
- GGT5 (leopard cat)
- GGT5 (wapiti)
- GGT5 (fence lizard)
- GGT5 (Arctic fox)
- GGT5 (rufous-necked snowfinch)
- GGT5 (white-rumped snowfinch)
- GGT5 (jaguarundi)
- GGT5 (common toad)
- GGT5 (common frog)
- GGT5 (scimitar-horned oryx)
- GGT5 (Barn swallow)
- GGT5 (large flying fox)
- GGT5 (Eurasian tree sparrow)
- GGT5 (Reeves's turtle)
- GGT5 (Tiger rattlesnake)
- GGT5 (striped hyena)
- GGT5 (leatherback sea turtle)
- GGT5 (Iberian mole)
- GGT5 (Jamaican fruit-eating bat)
- GGT5 (Sturnira hondurensis)
- GGT5 (Kuhl's pipistrelle)
- GGT5 (Myotis myotis)
- GGT5 (Pallas's mastiff bat)
- GGT5 (black swan)
- GGT5 (common lizard)
- GGT5 (Southern elephant seal)
- GGT5 (Trachemys scripta elegans)
- GGT5 (Pantherophis guttatus)
- GGT5 (Gaboon caecilian)
- GGT5 (Francois's langur)
- GGT5 (greater horseshoe bat)
- GGT5 (Abingdon island giant tortoise)
- GGT5 (vaquita)
- GGT5 (tufted duck)
- GGT5 (silvery gibbon)
- GGT5 (ring-necked pheasant)
- GGT5 (Kakapo)
- GGT5 (Microcaecilia unicolor)
- GGT5 (Aquila chrysaetos chrysaetos)
- GGT5 (Common wall lizard)
- GGT5 (pale spear-nosed bat)
- GGT5 (Steller sea lion)
- GGT5 (willow flycatcher)
- GGT5 (California sea lion)
- GGT5 (burrowing owl)
- GGT5 (eastern brown snake)
- GGT5 (mainland tiger snake)
- GGT5 (brown bear)
- GGT5 (emu)
- GGT5 (Okarito brown kiwi)
- GGT5 (Nothoprocta perdicaria)
- GGT5 (red fox)
- GGT5 (puma)
- GGT5 (dingo)
- GGT5 (gelada)
- GGT5 (Yangtze finless porpoise)
- GGT5 (common vampire bat)
- GGT5 (blue tit)
- GGT5 (Ugandan red Colobus)
- GGT5 (beluga whale)
- GGT5 (Hawaiian monk seal)
- GGT5 (white-rumped munia)
- GGT5 (helmeted guineafowl)
- GGT5 (koala)
- GGT5 (central bearded dragon)
- GGT5 (zebu cattle)
- GGT5 (great roundleaf bat)
- GGT5 (Australian saltwater crocodile)
- GGT5 (Gharial)
- GGT5 (leopard)
- GGT5 (Nanorana parkeri)
- GGT5 (black snub-nosed monkey)
- GGT5 (Malayan pangolin)
- GGT5 (Panamanian white-faced capuchin)
- GGT5 (Miniopterus natalensis)
- GGT5 (Egyptian rousette)
- GGT5 (Japanese quail)
- GGT5 (Taiwan habu)
- GGT5 (Great Tit)
- GGT5 (Gekko japonicus)
- GGT5 (cheetah)
- GGT5 (Common starling)
- GGT5 (ass)
- GGT5 (Thamnophis sirtalis)
- GGT5 (North Island brown kiwi)
- GGT5 (Swan goose)
- GGT5 (gray mouse lemur)
- GGT5 (Coquerel's sifaka)
- GGT5 (northern white-cheeked gibbon)
- GGT5 (sooty mangabey)
- GGT5 (drill)
- GGT5 (pig-tailed macaque)
- GGT5 (large flying fox)
- GGT5 (Arabian camel)
- GGT5 (Bactrian camel)
- GGT5 (bald eagle)
- GGT5 (Corvus cornix cornix)
- GGT5 (golden snub-nosed monkey)
- GGT5 (East African grey crowned-crane)
- GGT5 (White-tailed tropicbird)
- GGT5 (speckled mousebird)
- GGT5 (brown roatelo)
- GGT5 (chuck-will's-widow)
- GGT5 (sunbittern)
- GGT5 (Buceros rhinoceros silvestris)
- GGT5 (Macqueen's bustard)
- GGT5 (yellow-throated sandgrouse)
- GGT5 (Kea)
- GGT5 (chimney swift)
- GGT5 (red-crested turaco)
- GGT5 (common barn owl)
- GGT5 (cuckoo roller)
- GGT5 (hoatzin)
- GGT5 (white-tailed eagle)
- GGT5 (Downy woodpecker)
- GGT5 (killdeer)
- GGT5 (bar-tailed trogon)
- GGT5 (red-throated loon)
- GGT5 (Red-legged seriema)
- GGT5 (African ostrich)
- GGT5 (little egret)
- GGT5 (Northern fulmar)
- GGT5 (common cuckoo)
- GGT5 (great cormorant)
- GGT5 (Dalmatian pelican)
- GGT5 (crested ibis)
- GGT5 (Adelie penguin)
- GGT5 (emperor penguin)
- GGT5 (Common canary)
- GGT5 (rifleman)
- GGT5 (polar bear)
- GGT5 (American crow)
- GGT5 (Sunda flying lemur)
- GGT5 (Przewalski's horse)
- GGT5 (big brown bat)
- GGT5 (Philippine tarsier)
- GGT5 (Yangtze River dolphin)
- GGT5 (Burmese python)
- GGT5 (minke whale)
- GGT5 (sperm whale)
- GGT5 (tiger)
- GGT5 (Green sea turtle)
- GGT5 (black flying fox)
- GGT5 (Myotis davidii)
- GGT5 (Weddell seal)
- GGT5 (American alligator)
- GGT5 (alpaca)
- GGT5 (Wild Bactrian camel)
- GGT5 (Chinese tree shrew)
- GGT5 (water buffalo)
- GGT5 (Chinese alligator)
- GGT5 (wild yak)
- GGT5 (Brandt's bat)
- GGT5 (goat)
- GGT5 (Tibetan ground-tit)
- GGT5 (rock pigeon)
- GGT5 (white-throated sparrow)
- GGT5 (Saker falcon)
- GGT5 (medium ground-finch)
- Ggt5 (long-tailed chinchilla)
- GGT5 (western painted turtle)
- GGT5 (peregrine falcon)
- GGT5 (Collared flycatcher)
- GGT5 (mallard)
- GGT5 (domestic ferret)
- GGT5 (small Madagascar hedgehog)
- GGT5 (European shrew)
- GGT5 (American pika)
- GGT5 (Pacific walrus)
- GGT5 (killer whale)
- GGT5 (western lowland gorilla)
- GGT5 (sheep)
- GGT5 (domestic cat)
- GGT5 (Bolivian squirrel monkey)
- GGT5 (olive baboon)
- GGT5 (pygmy chimpanzee)
- GGT5 (small-eared galago)
- GGT5 (Tasmanian devil)
- GGT5 (African savanna elephant)
- ggt5 (tropical clawed frog)
- GGT5 (giant panda)
- GGT5 (white-tufted-ear marmoset)
- GGT5 (rabbit)
- ggt5b (zebrafish)
- GGT5 (zebra finch)
- GGT5 (pig)
- GGT5 (platypus)
- GGT5 (horse)
- GGT5 (gray short-tailed opossum)
- GGT5 (domestic cattle)
- GGT5 (dog)
- GGT5 (chimpanzee)
- GGT5 (chicken)
- Ggt5 (house mouse)
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate. Converts leukotriene C4 (LTC4), a glutathione-S-conjugate, to leukotriene D4 (LTD4). Does not cleave gamma-glutamyl compounds such as gamma-glutamyl leucine. May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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