Aadat - aminoadipate aminotransferase (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables 2-aminoadipate transaminase activity; kynurenine-glyoxylate transaminase activity; and kynurenine-oxoglutarate transaminase activity. Predicted to be involved in 2-oxoglutarate metabolic process; glutamate metabolic process; and kynurenine metabolic process. Is active in cytosol and mitochondrial matrix. Orthologous to human AADAT (aminoadipate aminotransferase).
- Kat2
- kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
- 2-aminoadipate aminotransferase
- 2-aminoadipate transaminase
- KAT/AadAT
- alpha-aminoadipate aminotransferase
- glycine transaminase AADAT
- kynurenine aminotransferase 2
- kynurenine aminotransferase II
- kynurenine--glyoxylate transaminase AADAT
- kynurenine--oxoglutarate aminotransferase II
- kynurenine--oxoglutarate transaminase 2
- kynurenine--oxoglutarate transaminase II
- methionine--glyoxylate transaminase AADAT
- 2-Aminoadipate Aminotransferase
- 2-Aminoadipate-2-Oxoglutarate Aminotransferase
- alpha-Aminoadipate Aminotransferase
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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