Nup93 - nucleoporin 93 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-20
Description
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nucleocytoplasmic transport; nucleus organization; and positive regulation of SMAD protein signal transduction. Located in nuclear envelope. Human ortholog(s) of this gene implicated in nephrotic syndrome type 12. Orthologous to human NUP93 (nucleoporin 93).
- nuclear pore complex protein Nup93
- 93 kDa nucleoporin
- nucleoporin 93kDa
- nucleoporin Nup93
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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