Capn2 - calpain 2 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables calcium ion binding activity; cytoskeletal protein binding activity; and enzyme binding activity. Contributes to calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including cellular response to interferon-beta; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of myoblast fusion. Located in several cellular components, including external side of plasma membrane; focal adhesion; and neuronal cell body. Biomarker of hypertrophic cardiomyopathy; sciatic neuropathy; and traumatic brain injury. Orthologous to human CAPN2 (calpain 2).
- calpain-2 catalytic subunit
- CANP 2
- M-calpain
- calcium-activated neutral proteinase 2
- calpain 2, (m/II) large subunit
- calpain II
- calpain M-type
- calpain-2 large subunit
- millimolar-calpain
- Ca2+-Activated Protease
- Calcium-Activated Neutral Protease
- Calcium-Activated Neutral Proteinase
- Calcium-Activated Protease
- Calcium-Dependent Neutral Protease
- Calpain II
- Calcium-Dependent Neutral Proteinase
- Calpain I
- Desminase
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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