Ube2v2 - ubiquitin conjugating enzyme E2 V2 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-14
Description
Involved in negative regulation of neuron apoptotic process; positive regulation of cellular component organization; and positive regulation of macromolecule metabolic process. Predicted to be located in nucleoplasm. Predicted to be part of UBC13-MMS2 complex. Predicted to be active in nucleus. Orthologous to human UBE2V2 (ubiquitin conjugating enzyme E2 V2).
- MMS2
- ubiquitin-conjugating enzyme E2 variant 2
- ubiquitin-conjugating enzyme E2v2
- ubiquitin-conjugating enzyme variant MMS2
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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