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PLCB1 - phospholipase C beta 1 (domestic cattle)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-14

1 Names and Identifiers

1.1 Synonyms

  • 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
  • PLC-154
  • PLC-I
  • PLC-beta-1
  • phosphoinositide phospholipase C
  • phosphoinositide phospholipase C-beta-1
  • phospholipase C, beta 1 (phosphoinositide-specific)

1.1.1 MeSH Entry Terms

  • 1-Phosphatidyl-D-myo-Inositol-4,5-bisphosphate Inositoltrisphosphohydrolase
  • 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase
  • PIP2-PLC
  • PIP2-Phosphoinositidase C
  • PPI Phosphodiesterase
  • Phosphatidylinositol-Specific Phospholipase C
  • Phosphatidylinositide-4,5-Bisphosphate Phospholipase C
  • Phosphatidylinositol-4,5-Biphosphate-Phosphodiesterase
  • Phosphoinositide Selective Phospholipase C
  • Phosphoinositol Specific Phospholipase C
  • Polyphosphoinositide Phosphodiesterase
  • Polyphosphoinositide Phospholipase C
  • PtdIns(4,5)P2 Phosphodiesterase
  • Tri-phosphoinositide Phosphodiesterase
  • Triphosphoinositide Phosphodiesterase

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Bgee Gene ID

1.2.3 Enzyme Commission (EC) Number

1.2.4 GlyCosmos Gene

1.2.5 VEuPathDB ID

3 Proteins

3.1 Protein Function

Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier.

3.2 Protein Targets

4 Interactions and Pathways

4.1 Interactions

4.2 Pathways

5 Biochemical Reactions

6 Expression

7 Literature

7.1 Consolidated References

7.2 NLM Curated PubMed Citations

7.3 Gene-Chemical Co-Occurrences in Literature

7.4 Gene-Gene Co-Occurrences in Literature

7.5 Gene-Disease Co-Occurrences in Literature

8 Patents

8.1 Gene-Chemical Co-Occurrences in Patents

8.2 Gene-Gene Co-Occurrences in Patents

8.3 Gene-Disease Co-Occurrences in Patents

9 Classification

9.1 MeSH Tree

10 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
    Phosphoinositide Phospholipase C
    https://meshb.nlm.nih.gov/record/ui?ui=D054801
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  6. NCBI Gene Expression Omnibus (GEO)
  7. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  8. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  9. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  10. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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