EEF1A1 - eukaryotic translation elongation factor 1 alpha 1 (domestic cattle)
- EF-1-alpha-1
- EF-Tu
- eEF1A-1
- elongation factor 1-alpha 1
- elongation factor Tu
- eukaryotic elongation factor 1 A-1
- EF-Tu
- Elongation Factor Tu
- Eucaryotic Elongation Factor Tu
- Protein Synthesis Elongation Factor Tu
- eEF-Tu
Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation. Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.
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