IKBKB - inhibitor of nuclear factor kappa B kinase subunit beta (domestic cattle)
- inhibitor of nuclear factor kappa-B kinase subunit beta
- I-kappa-B kinase 2
- I-kappa-B-kinase beta
- IKK-B
- IKK-beta
- IKK2
- NFKBIKB
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
- inhibitor of nuclear factor kappa B kinase beta subunit
- nuclear factor NF-kappa-B inhibitor kinase beta
- serine/threonine protein kinase IKBKB
- CHUK Kinase
- Conserved Helix-Loop-Helix Ubiquitous Kinase
- I Kappa B alpha-Associated Protein Kinase
- I kappa B Kinase
- IKK 1 Kinase
- IKBKB
- IKK gamma
- IKKepsilon
- IKK epsilon
- IKK 2 Kinase
- IkappaBalpha Kinase
- IkappaB Kinase alpha
- IKK alpha
- IkappaB Kinase
- IkappaB Kinase beta
- IkappaB Kinase epsilon
- IKK beta
- IkappaB Kinase gamma
- NF-kappaB Essential Modifier
- NK-kappa B-Activating Kinase NAK
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (By similarity). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (By similarity).
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