MORC1 - MORC family CW-type zinc finger 1 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-01
Description
This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]
Predicted to enable zinc ion binding activity. Predicted to be involved in cell differentiation and regulatory ncRNA-mediated gene silencing. Predicted to act upstream of or within several processes, including behavioral fear response; epigenetic regulation of gene expression; and negative regulation of DNA-templated transcription initiation. Predicted to be active in male germ cell nucleus.
- CT33
- MORC
- ZCW6
- MORC family CW-type zinc finger protein 1
- cancer/testis antigen 33
- microrchidia, mouse, homolog of
Required for spermatogenesis (By similarity). Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (By similarity).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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