Cyp4v3 - cytochrome P450, family 4, subfamily v, polypeptide 3 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-25
Description
Predicted to enable heme binding activity; iron ion binding activity; and long-chain fatty acid omega-hydroxylase activity. Predicted to be involved in fatty acid omega-oxidation. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2).
- Cyp4v2
- cytochrome P450 4V2
- cytochrome P450 4V3
- cytochrome P450-like protein
- docosahexaenoic acid omega-hydroxylase CYP4V2
- long-chain fatty acid omega-monooxygenase
A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs. Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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