Map3k3 - mitogen-activated protein kinase kinase kinase 3 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-29
Description
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel development and positive regulation of p38MAPK cascade. Predicted to be active in cytoplasm. Is expressed in several structures, including early conceptus; heart; and metanephros. Orthologous to human MAP3K3 (mitogen-activated protein kinase kinase kinase 3).
- MAPKKK3
- Mekk3
- mKIAA4031
- MAPK/ERK kinase kinase 3
- MEK kinase 3
- MEKK 3
- ERK Kinase Kinase 3
- MAP3K3 Protein Kinase
- MAPK-ERK Kinase Kinase 3
- MEK Kinase 3
- MEKK3 Protein Kinase
- Mitogen-Activated Protein Kinase Kinase Kinase 3
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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