Gnpda1 - glucosamine-6-phosphate deaminase 1 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-29
Description
Predicted to enable glucosamine-6-phosphate deaminase activity and identical protein binding activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process; amino sugar catabolic process; and generation of precursor metabolites and energy. Predicted to act upstream of or within fructose 6-phosphate metabolic process; fructose biosynthetic process; and glucosamine metabolic process. Located in cytoplasm. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human GNPDA1 (glucosamine-6-phosphate deaminase 1).
- GNPDA
- Gnp1
- Gnpi
- oscillin
- glucosamine-6-phosphate isomerase 1
- GNPDA 1
- glcN6P deaminase 1
- glucose-6-phosphate isomerase
- Autocrine Motility Factor
- Glucosephosphate Isomerase
- Isomerase, Glucose 6 Phosphate
- Neuroleukin
- Phosphoglucose Isomerase
- Phosphohexose Isomerase
- Tumor Autocrine Motility Factor
- Tumor-Cell Autocrine Motility Factor
- GNPDA1 (human)
- GNPDA1 (black-footed ferret)
- GNPDA1 (European mink)
- GNPDA1 (Ahaetulla prasina)
- GNPDA1 (red-backed fairy wren)
- GNPDA1 (Oenanthe melanoleuca)
- GNPDA1 (Chinese forest musk deer)
- GNPDA1 (raccoon dog)
- GNPDA1 (Leopard gecko)
- GNPDA1 (Pteronotus mesoamericanus)
- GNPDA1 (black-legged kittiwake)
- GNPDA1 (Aeolian wall lizard)
- GNPDA1 (graceful crag lizard)
- GNPDA1 (lesser prairie-chicken)
- GNPDA1 (takin)
- GNPDA1 (yellow-footed antechinus)
- GNPDA1 (California condor)
- GNPDA1 (Macaca thibetana thibetana)
- GNPDA1 (Northern goshawk)
- GNPDA1 (snow leopard)
- GNPDA1 (rock ptarmigan)
- GNPDA1 (Loggerhead turtle)
- GNPDA1 (Sphaerodactylus townsendi)
- GNPDA1 (Eurasian river otter)
- GNPDA1 (bobcat)
- GNPDA1 (greater spear-nosed bat)
- GNPDA1 (American black bear)
- GNPDA1 (Ring-tailed lemur)
- GNPDA1 (Agile Gracile Mouse Opossum)
- GNPDA1 (Komodo dragon)
- GNPDA1 (Asiatic toad)
- GNPDA1 (American mink)
- GNPDA1 (leopard cat)
- GNPDA1 (elk)
- GNPDA1 (fence lizard)
- GNPDA1 (Arctic fox)
- GNPDA1 (rufous-necked snowfinch)
- GNPDA1 (white-rumped snowfinch)
- GNPDA1 (jaguarundi)
- GNPDA1 (common toad)
- GNPDA1 (common frog)
- GNPDA1 (scimitar-horned oryx)
- GNPDA1 (Barn swallow)
- GNPDA1 (Eurasian tree sparrow)
- GNPDA1 (Reeves's turtle)
- GNPDA1 (Tiger rattlesnake)
- GNPDA1 (striped hyena)
- GNPDA1 (leatherback sea turtle)
- GNPDA1 (Iberian mole)
- GNPDA1 (Jamaican fruit-eating bat)
- GNPDA1 (Sturnira hondurensis)
- GNPDA1 (Kuhl's pipistrelle)
- GNPDA1 (Myotis myotis)
- GNPDA1 (Pallas's mastiff bat)
- GNPDA1 (black swan)
- GNPDA1 (common lizard)
- GNPDA1 (Southern elephant seal)
- GNPDA1 (Trachemys scripta elegans)
- GNPDA1 (Pantherophis guttatus)
- GNPDA1 (Gabon caecilian)
- GNPDA1 (Francois's langur)
- GNPDA1 (greater horseshoe bat)
- GNPDA1 (Abingdon island giant tortoise)
- GNPDA1 (vaquita)
- GNPDA1 (tufted duck)
- GNPDA1 (silvery gibbon)
- GNPDA1 (ring-necked pheasant)
- GNPDA1 (Kakapo)
- GNPDA1 (Microcaecilia unicolor)
- GNPDA1 (Aquila chrysaetos chrysaetos)
- GNPDA1 (Common wall lizard)
- GNPDA1 (pale spear-nosed bat)
- GNPDA1 (Steller sea lion)
- GNPDA1 (willow flycatcher)
- GNPDA1 (California sea lion)
- GNPDA1 (burrowing owl)
- GNPDA1 (eastern brown snake)
- GNPDA1 (mainland tiger snake)
- GNPDA1 (brown bear)
- GNPDA1 (emu)
- GNPDA1 (Okarito brown kiwi)
- GNPDA1 (Nothoprocta perdicaria)
- GNPDA1 (red fox)
- GNPDA1 (puma)
- GNPDA1 (dingo)
- GNPDA1 (gelada)
- GNPDA1 (Yangtze finless porpoise)
- GNPDA1 (common vampire bat)
- GNPDA1 (Ugandan red Colobus)
- GNPDA1 (beluga whale)
- GNPDA1 (Hawaiian monk seal)
- GNPDA1 (white-rumped munia)
- GNPDA1 (helmeted guineafowl)
- GNPDA1 (koala)
- GNPDA1 (central bearded dragon)
- GNPDA1 (zebu cattle)
- GNPDA1 (great roundleaf bat)
- GNPDA1 (Australian saltwater crocodile)
- GNPDA1 (Gharial)
- GNPDA1 (leopard)
- GNPDA1 (Nanorana parkeri)
- GNPDA1 (black snub-nosed monkey)
- GNPDA1 (Malayan pangolin)
- GNPDA1 (Panamanian white-faced capuchin)
- GNPDA1 (Miniopterus natalensis)
- GNPDA1 (Egyptian rousette)
- GNPDA1 (Japanese quail)
- GNPDA1 (Taiwan habu)
- GNPDA1 (Great Tit)
- GNPDA1 (Gekko japonicus)
- GNPDA1 (cheetah)
- GNPDA1 (Common starling)
- GNPDA1 (ass)
- GNPDA1 (Thamnophis sirtalis)
- GNPDA1 (North Island brown kiwi)
- GNPDA1 (Swan goose)
- GNPDA1 (gray mouse lemur)
- GNPDA1 (Coquerel's sifaka)
- GNPDA1 (sooty mangabey)
- GNPDA1 (drill)
- GNPDA1 (Colobus angolensis palliatus)
- GNPDA1 (pig-tailed macaque)
- GNPDA1 (large flying fox)
- GNPDA1 (Arabian camel)
- GNPDA1 (Bactrian camel)
- GNPDA1 (Bison bison bison)
- GNPDA1 (bald eagle)
- GNPDA1 (Corvus cornix cornix)
- GNPDA1 (golden snub-nosed monkey)
- GNPDA1 (common barn owl)
- GNPDA1 (Downy woodpecker)
- GNPDA1 (red-throated loon)
- GNPDA1 (little egret)
- GNPDA1 (common cuckoo)
- GNPDA1 (emperor penguin)
- GNPDA1 (Common canary)
- GNPDA1 (polar bear)
- GNPDA1 (American crow)
- GNPDA1 (Sunda flying lemur)
- GNPDA1 (Przewalski's horse)
- GNPDA1 (big brown bat)
- GNPDA1 (Philippine tarsier)
- GNPDA1 (green monkey)
- GNPDA1 (Yangtze River dolphin)
- GNPDA1 (Burmese python)
- GNPDA1 (minke whale)
- GNPDA1 (sperm whale)
- GNPDA1 (tiger)
- GNPDA1 (Green sea turtle)
- GNPDA1 (black flying fox)
- GNPDA1 (Myotis davidii)
- GNPDA1 (American alligator)
- GNPDA1 (alpaca)
- GNPDA1 (Wild Bactrian camel)
- GNPDA1 (Chinese tree shrew)
- GNPDA1 (Chinese soft-shelled turtle)
- GNPDA1 (little brown bat)
- GNPDA1 (water buffalo)
- GNPDA1 (Chinese alligator)
- GNPDA1 (wild yak)
- GNPDA1 (Brandt's bat)
- GNPDA1 (goat)
- GNPDA1 (crab-eating macaque)
- GNPDA1 (Tibetan ground-tit)
- GNPDA1 (rock pigeon)
- GNPDA1 (white-throated sparrow)
- GNPDA1 (Saker falcon)
- GNPDA1 (medium ground-finch)
- Gnpda1 (long-tailed chinchilla)
- GNPDA1 (western painted turtle)
- GNPDA1 (peregrine falcon)
- Gnpda1 (golden hamster)
- GNPDA1 (Collared flycatcher)
- GNPDA1 (mallard)
- GNPDA1 (domestic ferret)
- GNPDA1 (small Madagascar hedgehog)
- GNPDA1 (European shrew)
- GNPDA1 (American pika)
- GNPDA1 (nine-banded armadillo)
- GNPDA1 (Pacific walrus)
- GNPDA1 (killer whale)
- GNPDA1 (western lowland gorilla)
- GNPDA1 (sheep)
- GNPDA1 (domestic cat)
- GNPDA1 (Bolivian squirrel monkey)
- GNPDA1 (olive baboon)
- GNPDA1 (pygmy chimpanzee)
- GNPDA1 (small-eared galago)
- GNPDA1 (Tasmanian devil)
- GNPDA1 (African savanna elephant)
- GNPDA1 (northern white-cheeked gibbon)
- GNPDA1 (turkey)
- GNPDA1 (pig)
- GNPDA1 (giant panda)
- GNPDA1 (white-tufted-ear marmoset)
- gnpda1 (tropical clawed frog)
- GNPDA1 (rabbit)
- GNPDA1 (zebra finch)
- GNPDA1 (Sumatran orangutan)
- GNPDA1 (platypus)
- GNPDA1 (horse)
- GNPDA1 (gray short-tailed opossum)
- GNPDA1 (chimpanzee)
- GNPDA1 (Rhesus monkey)
- Gnpda1 (Norway rat)
- GNPDA1 (domestic cattle)
- GNPDA1 (dog)
- GNPDA1 (chicken)
Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling (By similarity). Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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