Hnf4a - hepatocyte nuclear factor 4, alpha (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-26
Description
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; anion binding activity; and long-chain fatty acyl-CoA hydrolase activity. Involved in several processes, including hepatocyte differentiation; negative regulation of non-membrane spanning protein tyrosine kinase activity; and positive regulation of biosynthetic process. Located in nucleus. Biomarker of hepatocellular carcinoma and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha).
- Hnf4
- Hnf4alpha
- hepatocyte nuclear factor 4-alpha
- HNF-4-alpha
- TCF-14
- alpha transcription factor 4
- hepatic nuclear factor 4, alpha
- nuclear receptor subfamily 2 group A member 1
- transcription factor 14
- transcription factor HNF-4
- HNF4 Transcription Factor
- Hepatocyte Nuclear Factor-Forkhead Homolog 4
- Hepatocyte Nuclear Factor 4-beta
- Hepatocyte Nuclear Factor 4-gamma
- Hepatocyte Nuclear Factor 4-alpha
- Nuclear Receptor Subfamily 2, Group A, Member 1
- Nuclear Receptor Subfamily 2 Group A, Member 2
Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (By similarity). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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