Slc11a2 - solute carrier family 11 member 2 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables lead ion transmembrane transporter activity; transition metal ion binding activity; and transition metal ion transmembrane transporter activity. Involved in several processes, including cellular response to hypoxia; cellular response to tumor necrosis factor; and transition metal ion transport. Located in apical part of cell; late endosome membrane; and lysosomal membrane. Used to study Parkinsonism; hypochromic anemia; and pneumonia. Biomarker of brain ischemia; duodenal ulcer; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2).
- Dmt1
- Nramp2
- natural resistance-associated macrophage protein 2
- DMT-1
- NRAMP 2
- Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2)
- divalent cation transporter 1
- divalent metal transporter 1
- solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
- solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PMID: 16091957, PMID: 9242408). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (By similarity) (PMID: 16091957, PMID: 29317744, PMID: 9242408). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity) (PMID: 9242408). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (PMID: 29317744). Can mediate uncoupled fluxes of either protons or metal ions.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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