Dbh - dopamine beta-hydroxylase (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables copper ion binding activity and dopamine beta-monooxygenase activity. Involved in several processes, including cellular response to manganese ion; cellular response to nicotine; and norepinephrine biosynthetic process. Located in several cellular components, including axon; dendrite; and neuronal cell body. Biomarker of brain ischemia; depressive disorder; hypertension; and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase).
- DOPBHY
- Dopamine beta hydroxylase (dopamine beta-monooxygenase)
- dopamine beta-monooxygenase
Dopamine beta-Monooxygenase
Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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