Pcmt1 - protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-27
Description
Enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Involved in several processes, including S-adenosylhomocysteine metabolic process; cellular response to hypoxia; and negative regulation of cardiac muscle cell apoptotic process. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and perikaryon. Biomarker of high grade glioma. Orthologous to human PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase).
- PCM
- protein-L-isoaspartate(D-aspartate) O-methyltransferase
- L-isoaspartyl protein carboxyl methyltransferase
- PIMT
- protein L-isoaspartyl/D-aspartyl methyltransferase
- protein-beta-aspartate methyltransferase
- D-Aspartyl-L-Isoaspartyl Methyltransferase
- Isoaspartyl-Aspartyl Protein Methyltransferase
- L-Isoaspartyl Protein Carboxymethyltransferase
- Methyltransferase PIMT
- PCMT1 Gene Product
- Protein L-Isoaspartate O-Methyltransferase
- Protein L-Isoaspartyl Methyltransferase
- Protein-D-Asp Methyltransferase
- Protein-L-Isoaspartate-D-Aspartate-O-Methyltransferase
- Protein-D-Aspartate Methyltransferase
- Protein-L-Isoaspartate Methyltransferase
- Protein-beta-Aspartate Methyltransferase
- pcm Gene Product
Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (By similarity). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- STRING: functional protein association networks
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