Id2 - inhibitor of DNA binding 2 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Predicted to enable several functions, including transcription corepressor activity; transcription regulator inhibitor activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; negative regulation of macromolecule biosynthetic process; and positive regulation of cell population proliferation. Located in chromatin; cytoplasm; and nucleus. Orthologous to human ID2 (inhibitor of DNA binding 2).
- Ac2-300
- DNA-binding protein inhibitor ID-2
- inhibitor of DNA binding 2, HLH protein
- inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
- inhibitor of differentiation 2
- DNA-Binding Protein Inhibitor ID-2
- Inhibitor of DNA Binding 2 Protein
- Inhibitor of Differentiation 2 Protein
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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