PCSK9 - proprotein convertase subtilisin/kexin type 9 (human)
- Create:2016-09-14
- Modify:2025-01-29
The PCSK9 gene provides instructions for making a protein that helps regulate the amount of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that is produced in the body and obtained from foods that come from animals.
The PCSK9 protein controls the number of low-density lipoprotein receptors, which are proteins on the surface of cells. These receptors play a critical role in regulating blood cholesterol levels. The receptors bind to particles called low-density lipoproteins (LDLs), which are the primary carriers of cholesterol in the blood. Low-density lipoprotein receptors are particularly abundant in the liver, the organ responsible for removing most excess cholesterol from the body.
The number of low-density lipoprotein receptors on the surface of liver cells determines how quickly cholesterol is removed from the bloodstream. The PCSK9 protein breaks down low-density lipoprotein receptors before they reach the cell surface, so more cholesterol can remain in the bloodstream.
- FH3
- FHCL3
- HCHOLA3
- LDLCQ1
- NARC-1
- NARC1
- PC9
- convertase subtilisin/kexin type 9 preproprotein
- neural apoptosis regulated convertase 1
- subtilisin/kexin-like protease PC9
- NARC-1 Protein
- Neural Apoptosis-Regulated Convertase 1
- Proprotein Convertase, Subtilisin-Kexin Type 9
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