Ggh - gamma-glutamyl hydrolase (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables gamma-glutamyl-peptidase activity. Involved in several processes, including response to ethanol; response to insulin; and response to zinc ion. Located in extracellular space. Orthologous to human GGH (gamma-glutamyl hydrolase).
- GH
- conjugase
- gamma-Glu-X carboxypeptidase
- gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
- Carboxypeptidase G
- Carboxypeptidase G1
- Carboxypeptidase G2
- Conjugase
- Folacin Conjugase
- Folate Hydrolyzing Enzyme
- Folylpolyglutamate Hydrolase
- Folyl Conjugate Synthetase
- Folyl Poly-gamma-Glutamate Carboxypeptidase
- Folyl Polyglutamate Cleavage Enzyme
- Folate Conjugase
- Pteroyl Polyglutamate Hydrolase
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates (PMID: 8343522, PMID: 8621474). Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Exhibits either endo- or exopeptidase activity depending upon the tissue of origin. When secreted, it acts primarily as an endopeptidase (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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