Alad - aminolevulinate dehydratase (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables porphobilinogen synthase activity and proteasome core complex binding activity. Involved in several processes, including cellular response to lead ion; response to herbicide; and response to vitamin B1. Located in extracellular space. Used to study anemia and hemochromatosis. Biomarker of acute kidney failure; hypothyroidism; liver cirrhosis; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase).
- ALADH
- ALADR
- delta-aminolevulinic acid dehydratase
- aminolevulinate, delta-, dehydratase
- aminolevulinatedelta-dehydratase
- delta - aminolevulinic acid dehydratase
- porphobilinogen synthase
- ALA-Dehydrase
- Aminolevulinate Hydro-Lyase
- Aminolevulinic Acid Dehydratase
- delta-Aminolevulinate Dehydratase
- delta-Aminolevulinic Acid Dehydratase
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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