Abcc2 - ATP binding cassette subfamily C member 2 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-19
Description
Enables ABC-type transporter activity; bilirubin transmembrane transporter activity; and protein domain specific binding activity. Involved in several processes, including carboxylic acid transport; cellular response to cytokine stimulus; and cellular response to dexamethasone stimulus. Located in brush border membrane and intracellular canaliculus. Used to study Dubin-Johnson syndrome; bilirubin metabolic disorder; cholestasis; end stage renal disease; and epilepsy. Biomarker of bilirubin metabolic disorder; cholestasis; liver disease (multiple); status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2).
- Cmoat
- Mrp2
- cMRP
- mrp
- ATP-binding cassette sub-family C member 2
- ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- ATP-binding cassette, subfamily C (CFTR/MRP), member 2
- cMrp2/cMoat canalicular apical conjugate export pump
- calicular multispecific organic anion transporter
- canalicular multidrug resistance protein
- canalicular multispecific organic anion transporter 1
- multidrug resistance-associated protein 2
- ABCC2 Protein
- CMOAT Protein
- CMOAT Transport Protein
- CMOAT
- Canalicular Multispecific Organic Anion Transporter
- MRP2 Protein, Multidrug Resistance
- MRP2 Transport Protein
- Multidrug Resistance Protein MRP2
- Multidrug-Resistance Associated Protein 2
ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PMID: 10220572, PMID: 10421658, PMID: 11248200, PMID: 8662992). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PMID: 10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PMID: 10220572, PMID: 8662992). Transports sulfated bile salt such as taurolithocholate sulfate (PMID: 11248200). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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